Mesenchymal Stem Cell Therapy

What are Stem Cells?

Our body is made up of trillions of cells. These cells begin as stem cells which then replicate and mature into many different types of cells in the body. Hematopoietic stem cells give rise to all of the blood cells in our body. For regenerative pain purposes, however, we use a different type of stem cell called mesenchymal stem cells. These mesenchymal stem cells have the ability to help the body repair itself. Mesenchymal stem cells communicate with other damaged cells through a process called “paracrine signaling”. This paracrine signaling process directs and controls the natural regeneration or healing process in our bodies. Nashville Stem Cell Therapy utilizes these mesenchymal stem cells to help the body naturally repair itself.  Our Nashville Stem Cell Therapy provides a natural source to help with pain and various disease processes.

What are the benefits of Nashville Stem Cell Therapy?

  1. Stem cells are anti-inflammatory and immunomodulatory. They can decrease swelling and inflammation in the body by downregulating/decreasing the T-1 helper cells (pro-inflammatory cells) and upregulating/increasing the T-2 helper cells (anti-inflammatory cells). Many chronic pain states and systemic diseases have an imbalance of T1/T2 helper cells. Stem cells can help restore balance, thus decreasing inflammation and swelling in the body. This is especially helpful with chronic pain states and many autoimmune disorders.
  2. Stem cells have trophic/growth factors that help nourish nearby cells that are damaged.  They increase blood supply to damaged tissue and can help reduce scar tissue formation.
  3. Stem cells signal nearby cells that are about to die and help rescue those cells from cell death. It cannot heal cells that are already dead, but can help save those damaged cells that are about to die.
  4. Stem cells have antimicrobial properties that help fight bacterial infections. This is very beneficial for wound healing.
  5. Stem cells have the potential to do many functions that other cells in your body already do. They have the potential to regenerate damaged tissues and help avoid surgery.
  6. Research studies have shown patients to have significant improvements in pain and function as well as improvements on MRI several years after only one stem cell injection. Stem cell therapy is very exciting because it has the potential to help correct the source of your pain.

What medical conditions could potentially benefit from Nashville Stem Cell Therapy ?

  • Osteoarthritis
  • Degenerative joint disease
  • Knee pain including knee osteoarthritis, degenerative joint disease, meniscal tears and ACL/PCL tears.  Research studies have shown cartilage growth and repair after just one stem cell injection.
  • Shoulder pain including rotator cuff injuries, arthritis etc.
  • Hip pain
  • Chronic pain disorders including chronic lower back and neck pain.

How are stem cells collected?

There are multiple ways that donor mesenchymal stem cells can be collected in order to inject or infuse into your body. Stem cells are collected from four sources for the purpose of regenerative therapy.  These four sources include bone marrow, adipose tissue, amniotic fluid and umbilical cord blood.

1. Stem cells can be extracted from your bone marrow.  This technique involves puncturing a needle through your bone and extracting the marrow.  The marrow is then filtered to get the stem cells.

2. Stem cells can be extracted from your adipose tissue.  This technique involves using a needle to remove fat cells from your body.  The fat cells are then filtered to obtain stem cells. Both bone marrow aspirate and adipose derived fat stem cells can be a painful and time consuming process. The stem cell count from both of these methods is variable.  The cell count varies according to the patient’s age, health, and technique of the provider extracting the stem cells.

3. Stem cells can be extracted from amniotic fluid.  This method involves collecting stem cells from amniotic fluid in a pregnant woman. This method has a potential risk of causing an autoimmune reaction in your body due to HLA antigens in cellular debris.  The stem cell count from amniotic fluid is variable. These three methods produce a variable number of stem cells.  An accurate cellular count is important because some joints require more cells than others.

4. The last way to obtain stem cells is through umbilical cord blood of live, healthy birthed babies.  These stem cells are not from aborted fetuses and are in no way related to abortions.  The umbilical cord is removed after a live, healthy child is born. Blood from within the cord has stem cells which are saved and sent to a tissue bank.  The tissue bank runs tests on the stem cells to ensure that they are healthy and free of disease. These stem cells are then frozen and stored at a tissue bank under strict FDA compliance.  They are regulated and processed by the American Association of Tissue Banks (AATB).

Which type of stem cells does Nashville Stem Cell Therapy use?

Nashville Stem Cell Therapy uses umbilical cord blood derived stem cells. We believe that cord blood is the superior method for extracting stem cells. These umbilical cord blood stem cells are young, healthy and robust cells. Stem cells from bone marrow and adipose tissue are the same age as the person donating them. HLA antigens are attached to cells and are what our bodies use to recognize a cell as being foreign and therefore reject.  These umbilical cord blood stem cells do not have HLA antigens attached to them.  This means that an adverse reaction to the stem cells from umbilical cord blood is far less likely and much safer.


Umbilical cord derived Stem Cell with fluorescent staining
Umbilical cord derived Stem Cell with fluorescent staining


Another advantage of umbilical cord blood derived stem cells is that the cell count is more accurate and customizable for individual needs. For example, a large joint would require more cells than a smaller joint would. We can approximate the number of cells you may need for your specific disease process. We offer Nashville Stem Cell Therapy at our Nashville and Hendersonville interventional pain management clinics.

Final comments

We believe that regenerative medicine with treatments such as stem cell therapy are the future of medicine, personal health and longevity. Nashville Stem Cell Therapy is an exciting, regenerative treatment that has the potential to help with many disease processes. The goal for our patients at our interventional pain clinics is to help reduce pain, improve function and improve quality of life. Nashville Stem Cell Therapy has the potential to help with all of these. If you would like more information or would like to set up an appointment to discuss our Nashville Stem Cell Therapy with one of our board-certified physicians, please call us at Interventional Pain Center (615) 972-1100 located in Nashville and Hendersonville, TN.